Key takeaways
- Attruby (acoramidis) is a prescription drug that’s used to treat transthyretin-mediated amyloidosis cardiomyopathy (ATTR-CM).
- Attruby comes as an oral tablet.
- Attruby contains the active ingredient acoramidis and is a brand-name medication. A generic version of Attruby isn’t currently available.
Attruby is taken to treat wild-type or variant transthyretin-mediated amyloidosis cardiomyopathy (ATTR-CM) to reduce the risk of hospitalization and death due to heart problems. Attruby is prescribed for adults for this use.
When you have ATTR-CM, your body makes flawed versions of a protein called transthyretin. Clumps of these flawed versions deposit in your heart muscle. This clumping stiffens the walls of your heart, making it harder for your heart to pump blood.
This condition may cause symptoms such as:
- shortness of breath
- arrhythmia or heart palpitations
- chest pain
Attruby video with Morgan Freeman
Morgan Freeman has partnered with the makers of Attruby to share about how the drug may help people with ATTR-CM. He does not live with ATTR-CM.
Attruby’s mechanism of action (moa)
Attruby works to treat ATTR-CM by making the transthyretin protein more stable. It helps your body form proper versions of transthyretin. In turn, this action slows the rate at which the flawed protein clumps are deposited in your heart muscle.
Like most drugs, Attruby may cause mild to serious side effects. The lists below contain some of the more common side effects Attruby may cause. But they don’t include all side effects possible.
Keep in mind that side effects of a drug can depend on:
- your age
- other health conditions you have
- other medications you take
Your doctor or the pharmacy filling your prescription can tell you more about the potential side effects of Attruby. They can also suggest ways to help reduce side effects.
Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Sharing your experience helps make medications safer for everyone by giving doctors and researchers more information about how the drug works in real life. If you develop a side effect while taking Attruby and want to tell the FDA about it, visit MedWatch or call 800-FDA-1088.
Mild side effects
Mild side effects of Attruby that have been reported include:
- diarrhea
- pain in the upper abdomen
- mild increases in blood creatinine
Mild side effects of many drugs may go away within a few days to a couple of weeks. But if they become bothersome, talk with your doctor or the pharmacy filling your prescription.
Serious side effects
Serious side effects are not reported in Attruby’s prescribing information, but they are still possible. For example, serious side effects that didn’t occur in the drug’s clinical studies could be discovered later.
If you think you’re having a serious side effect from Attruby, call your doctor right away. But if you think you’re having a medical emergency, call 911. Or call your local emergency number.
ALLERGIC REACTIONFor some people, Attruby can cause an allergic reaction. But this side effect wasn’t reported in the drug’s studies.
In general, symptoms of allergic reaction can be mild or serious.
What might help
If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest a treatment to manage your symptoms. They can also determine whether you should keep taking Attruby.
If you have symptoms of a severe allergic reaction, such as swelling or difficulty breathing, call 911. Or call your local emergency number right away. These symptoms could be life threatening and require immediate medical care.
Your doctor can confirm whether you’ve had a serious allergic reaction to Attruby. If they do, they may have you switch to a different treatment.
Your doctor will recommend the dosage of Attruby that’s right for you. The information below describes commonly used dosages, but always take the dosage your doctor prescribes. If you have questions about Attruby dosing, talk with your doctor or the pharmacy filling your prescription.
Form and strength
Attruby is available as an oral tablet in one strength of 356 milligrams (mg).
Recommended dosage
For treating ATTR-CM, your doctor will likely prescribe an Attruby dosage of 712 mg twice daily. This means one dose is two 356-mg tablets.
About taking Attruby
Below are some common questions about taking Attruby.
- Can Attruby be chewed, crushed, or split? No, you should not chew, crush, or split Attruby tablets. You should swallow them whole. If you have difficulty doing so, you can get tips on how to swallow pills. Or you can ask your doctor or the pharmacy filling your prescription for advice.
- Should I take Attruby with food? You can take Attruby with or without food.
- Is there a best time of day to take Attruby? You can take Attruby at any time of day, but it’s best to take it around the same time each day. This helps keep a consistent level of the drug in your body, which helps Attruby work effectively.
- What if I miss a dose of Attruby? If you miss a dose of Attruby, take it as soon as you remember. But if it’s almost time to take your next dose, skip the missed dose. Then take your next dose at its usual time. You should not take two doses at once to make up for a missed dose. Doing so could raise your risk of side effects.
- Will I need to take Attruby long term? People typically take Attruby as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.
- How long does Attruby take to work? Attruby begins to work after you take your first dose. But you likely won’t feel the drug working in your body. Your doctor will order tests throughout your treatment to check whether Attruby is working to treat your condition.
Overdose
Do not take more Attruby than your doctor prescribes, as this can lead to harmful effects.
What to do in case you take too much Attruby
Call your doctor if you think you’ve taken too much Attruby. You can also call 800-222-1222 to reach Poison Help or use its online resource. But if you have severe symptoms, immediately call 911 or your local emergency number. Or go to the nearest emergency room.
Taking a drug with certain medications, vaccines, foods, and other things can affect how the drug works. These effects are called interactions. Attruby can interact with several other medications and certain supplements.
Before starting treatment with Attruby, talk with your doctor and the pharmacy filling your prescription. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you take. Sharing this information can help you avoid potential interactions.
Interactions with medications
Below is a list of medications that can interact with Attruby. This list does not contain all drugs that may interact with Attruby.
| Drug group or drug name | Drug examples |
|---|---|
| certain anti-androgen drugs | • apalutamide (Erleada) • enzalutamide (Xtandi) |
| certain antiepileptic drugs | • carbamazepine (Tegretol, others) • phenytoin (Dilantin) |
| rifampin (Rimactane) | — |
| ritonavir (Norvir) and treatments that contain it | • Kaletra (lopinavir/ritonavir) • Paxlovid (nirmatrelvir/ritonavir) |
| celecoxib (Celebrex) | — |
If you have questions about drug interactions that may affect you, ask your doctor or the pharmacy filling your prescription.
Attruby and alcohol
Alcohol is not known to interact with Attruby. But alcohol may worsen ATTR-CM. Because of this, your doctor may recommend that you limit the amount of alcohol you drink during treatment with Attruby.
Supplements
Attruby interacts with St. John’s wort. This is an herbal supplement taken to treat symptoms of depression and certain other medical conditions. St. John’s wort can make Attruby less effective if they’re taken together.
Your doctor will likely recommend that you avoid taking this supplement during your Attruby treatment. They can discuss other treatments for your symptoms.
The following is important information to consider and discuss with your doctor or pharmacist before taking Attruby.
Pregnancy and breastfeeding
It’s not known whether it’s safe to take Attruby during pregnancy or while breastfeeding. If you’re pregnant or breastfeeding or planning either, talk with your doctor before starting treatment with Attruby.
Attruby can sometimes cause harmful effects in people who have certain conditions. This is known as a drug-condition interaction. Other factors may also affect whether Attruby is a good treatment option for you.
Talk with your doctor about your health history before you take Attruby. Be sure to tell them if any of the following factors apply to you:
- a kidney condition, such as chronic kidney disease
- past allergic reaction to Attruby
- pregnancy
- breastfeeding
Note: For more information about the potential negative effects of Attruby, see the “Side effects of Attruby” section.
Here are answers to some commonly asked questions about Attruby.
Attruby and Vyndamax are similar medications. Both Attruby and Vyndamax are prescribed for adults to treat ATTR-CM. Both drugs also belong to the same drug class.
Dosing for the two drugs differs. You usually take Attruby twice daily, while you usually take Vyndamax once daily. Attruby comes as an oral tablet, while Vyndamax is available as an oral capsule.
If you’d like to learn more about how Attruby and Vyndamax compare, talk with your doctor or the pharmacy filling your prescription.
No, Attruby is not a cure for ATTR-CM. Currently, a cure for this condition is not known. But Attruby can slow the progression of ATTR-CM and its symptoms. Studies have shown that Attruby lowers the risk of hospitalization and death due to heart problems in adults who have ATTR-CM.
Talk with your doctor if you have other questions about what to expect from your treatment with Attruby.
Whether or not you have health insurance, Attruby’s cost may be a factor when you’re considering treatment. What you’ll pay for Attruby may depend on several things, such as your treatment plan and your insurance coverage.
If you have questions about how to pay for your prescription, talk with your doctor or the pharmacy filling your prescription. You might also consider a savings program called ForgingBridges, available for Attruby manufacturer BridgeBio Pharma, Inc., which may help provide more information on Attruby’s price and your cost.
Other drugs are available that can treat your condition. If you’d like to explore an alternative to Attruby, talk with your doctor. They can tell you about other medications that might work for you.
The following drugs are similar to Attruby:
Disclaimer: While Healthline strives for factual, comprehensive, and current information, this article is not a substitute for a licensed healthcare professional’s expertise. Always consult a doctor before taking or discontinuing any medication. Drug information is subject to change and may not cover all uses, directions, precautions, warnings, interactions, reactions, or adverse effects. The lack of a warning does not guarantee a drug’s safety, effectiveness, or appropriateness for all patients or specific uses. Learn more about our approach to content integrity.