Key takeaways

  • Yorvipath (palopegteriparatide), which is used to treat underactive parathyroid glands in adults, can cause side effects that range from mild to serious.
  • More common side effects include injection site reactions, diarrhea, and back pain.
  • Some side effects may be temporary, lasting a few days to weeks. But if side effects do not go away, get worse, or become too difficult to tolerate, talk with your doctor.

Yorvipath is used in adults to treat:

Keep reading to learn about the common, mild, and serious side effects Yorvipath can cause. To learn more about this medication, including its uses, dosage, and cost, read this Yorvipath overview.

Yorvipath can cause certain side effects, some more common than others. These side effects may be temporary, lasting a few days to weeks. Talk with your doctor if side effects do not go away, get worse, or become too difficult to tolerate.

Yorvipath’s commonly reported side effects include:

  • injection site reactions
  • vasodilatory (widening of the blood vessels) signs and symptoms, which may include symptoms such as:
    • decreased blood pressure
    • feeling lightheaded when standing
  • headache
  • diarrhea
  • back pain

Mild side effects have been reported with Yorvipath. These include:

  • injection site reactions
  • vasodilatory (widening of the blood vessels) signs and symptoms
  • headache
  • diarrhea
  • back pain
  • mild high calcium blood levels
  • sore throat

In most cases, these side effects should be temporary, and some may be easily managed. But if you have symptoms that are ongoing or bothersome, talk with your doctor or pharmacist. Do not stop Yorvipath treatment unless your doctor recommends it.

Yorvipath may cause mild side effects other than those listed here. See the drug’s prescribing information for details.

For more information about some of these side effects, see “Tips for managing side effects.”

Yorvipath may cause serious side effects. The following list may not include all possible serious side effects of the drug. For more information, you can refer to Yorvipath’s prescribing information.

If you develop serious side effects while taking Yorvipath, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Serious side effects that have been reported include:

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Sharing your experience helps make medication safer for everyone by giving doctors and researchers more information about how the drug works in real life. If you develop a side effect during treatment with Yorvipath and want to tell the FDA about it, visit MedWatch or call 800-FDA-1088.

Allergic reaction

For some people, Yorvipath can cause an allergic reaction. But it’s not clear whether this side effect occurred in the drug’s studies.

In general, symptoms of an allergic reaction can be mild or serious.

What might help

If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest a treatment to manage your symptoms and can determine whether you should continue Yorvipath treatment.

If you have symptoms of a severe allergic reaction, such as swelling or difficulty breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care.

If your doctor confirms you’ve had a serious allergic reaction to Yorvipath, they may have you switch to a different treatment.

There may be things you can do to help make certain Yorvipath side effects more manageable. If you have ongoing, worsening, or bothersome side effects, talk with your doctor or pharmacist. They can suggest tips for managing them or recommend other available treatment options for your condition.

Diarrhea

Diarrhea was a common side effect reported in studies of Yorvipath. Steps you can take to manage symptoms associated with this side effect include:

  • taking over-the-counter antidiarrheal medications
  • maintaining adequate hydration
  • drinking electrolytes
  • eating bland, easy-to-digest foods, such as the BRAT diet

Back pain

Back pain was a common side effect reported in studies of Yorvipath. Steps you can take to manage symptoms associated with this side effect include:

  • taking over-the-counter pain medications
  • applying cold or heat therapies to reduce inflammation and pain
  • engaging in gentle exercise or stretching as tolerated
  • seeing a physical therapist

Before taking Yorvipath, discuss your health history with your doctor. Yorvipath may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if any of the following apply to you:

  • high or low calcium blood levels
  • history of certain bone disease, such as Paget disease of bone
  • taking medications that contain digoxin
  • history of external beam or implant radiation therapy involving the skeleton
  • history of bone cancer
  • hereditary conditions that may contribute to bone cancer
  • elevated alkaline phosphatase levels
  • previous allergic reaction to this or a similar drug
  • pregnancy
  • breastfeeding

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.