The usual Monjuvi dosage for lymphoma is 12 milligrams per kilogram of body weight, given via intravenous infusion. It’s given in 28-day treatment cycles, and you’ll receive infusions on certain days each cycle.
Monjuvi is used in adults to treat certain types of diffuse large B cell lymphoma that have come back after treatment or are not responding to other drugs.
The active ingredient in Monjuvi is tafasitamab-cxix. Monjuvi is a biologic drug, which means it’s made from living cells.
This article describes the dosages of Monjuvi, as well as its strength and how it’s given. To learn more about Monjuvi, see this in-depth Monjuvi article.
This dosage chart highlights the basics of Monjuvi’s dosage. Be sure to read on for more detail.
| Monjuvi form | Monjuvi strength | Usual dosage |
|---|---|---|
| powder that’s mixed with sterile water to form a liquid solution | 200 milligrams (mg) | 12 mg per kilogram (kg) body weight |
Monjuvi form
Monjuvi comes as a powder, which is mixed with a specific amount of sterile water to make a liquid solution. It’s given as an intravenous (IV) infusion (an injection into a vein given over time) by a healthcare professional.
Monjuvi strength
Monjuvi comes in one strength of 200 mg of powder in a single-dose vial.
Monjuvi’s dosage is based on body weight: 12 mg per kilogram (12 mg/kg). Your doctor will make your dosage calculations by weight. For example, if your body weight is 75 kg, your Monjuvi dose will be 900 mg.
Diffuse large B cell lymphoma is treated on a certain number of days per cycle and a cycle lasts 28 days. For example, the first 28-day period is called cycle 1, the next is called cycle 2, and so on.
The manufacturer recommends that your Monjuvi dose be given more often in the earlier part of your treatment according to the following schedule:
- For cycle 1, you’ll be given Monjuvi on days 1, 4, 8, 15, and 22.
- For cycles 2 and 3, you’ll be given Monjuvi on days 1, 8, 15, and 22.
- For cycles 4 to 12 and any cycles after that, you’ll be given Monjuvi on days 1 and 15.
Monjuvi is usually given with lenalidomide (Revlimid) for 12 cycles. You’ll typically continue taking Monjuvi by itself after finishing with Revlimid treatment.
This dosing schedule is most commonly used or recommended. But your doctor will determine the best dosage to fit your needs.
Dosage adjustments
Your doctor will test your blood for levels of certain blood cells and watch you for signs of infection. Depending on how the drug affects your body, they may lower your Monjuvi dose or pause your treatment for a period of time.
Your doctor will also monitor you for reactions that happen right at the time of your dosage. If your body has a negative reaction to the drug, they may give your infusion more slowly, pause it, or switch you to a different medication.
You’ll usually go to a doctor’s office, healthcare facility, or infusion center to get your Monjuvi intravenous (IV) infusion.
Your first infusion will be a little slower and can take as long as 2.5 hours. If your body does not react badly, future infusions will usually take between 1.5 and 2 hours.
You may be told to arrive early so you can be given premedications 30 minutes to 2 hours before your Monjuvi dose. These are medications that help your body avoid negative reactions to the infusion.
If you get three infusions and have no bad reactions, your doctor may allow you to skip this step later.
How long do you take Monjuvi?
Monjuvi is usually used as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely receive it long term.
Monjuvi’s manufacturer recommends taking the drug until your cancer gets worse or you have side effects that are severe or can’t be tolerated. Talk with your doctor about tests they’ll do to track Monjuvi benefits and risks over time.
If you miss or know you’ll have to miss your Monjuvi dosage appointment, contact the place where you receive your infusions or reach out to your doctor. They’ll help you reschedule it as soon as possible.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.