Syfovre (pegcetacoplan) is given as an eye injection by your doctor, typically once every 25 to 60 days.
Syfovre belongs to a group of drugs called complement inhibitors. Its active ingredient is pegcetacoplan.
Syfovre is available as a liquid solution that’s delivered as an injection directly into the eye. This is called an intravitreal injection. The drug comes in only one strength: 150 milligrams per milliliter (mg/mL).
You’ll always receive Syfovre at your doctor’s office. The typical dose is 15 mg injected into each affected eye once every 25 to 60 days.
A doctor may adjust this dose depending on your individual needs and they will also determine if you need it more or less often.
The table below highlights the basics of Syfovre’s dosage.
| Form | Strength | Typical Syfovre dosage |
| liquid solution that’s given as an intravitreal injection by a doctor | 150 mg/mL | 15 mg in each affected eye once every 25 to 60 days |
At the doctor’s office, they’ll ask you to sit in a reclining chair. The doctor or an assistant will then clean your eyelids and the surface of your eye. They may also use a topical antibiotic to reduce the risk of infection.
After this, they will apply numbing drops in your eyes. Numbing gel or anesthetic injections may be used instead.
Before each injection, the doctor will also check the pressure in your eye. If this pressure is high, they may give you another medication to lower it before the Syfovre injection.
Once you’re ready to receive Syfovre, the doctor may use a small device to gently hold your eyelids open so you don’t blink.
The doctor will ask you to look in a certain direction, and then use a very fine needle to inject Syfovre into the white part of your eye.
The injection itself usually takes only a few seconds. You may feel pressure or a quick pinch as they inject the medication, but not sharp pain. You may want to ask your doctor if you should alert them about any specific sensations during the injections.
After the Syfovre injection, the doctor will check your eye. Your vision may be blurry for some time, and you may also have a scratchy feeling, redness, and a small bubble or spot that will gradually go away.
You can usually go home the same day, but the doctor will advise you to avoid driving, operating machinery, and other similar activities.
When to seek care after an injection
Once you go home, seek immediate medical care if you experience any of the following symptoms:
- increasing pain (not just irritation)
- worsening redness
- swollen eyelids
- light sensitivity
- sudden vision loss
- heavy floaters (floating shapes in your vision)
- green or thick discharge
These are all rare but serious symptoms, because they could be signs of an infection or inflammation.
Yes, Syfovre is typically used as a long-term treatment for geographic atrophy, an advanced form of dry age-related macular degeneration. Because the condition is chronic and progressive, Syfrovre is an ongoing maintenance treatment.
If you and your doctor determine that the injections are safe and effective for your condition, you’ll likely receive Syfovre injections for life.
The dose of Syfovre will remain the same throughout treatment. There is no dose escalation or tapering, though a doctor may adjust the frequency of your injections. Some retina specialists may start monthly and then extend to every other month or adjust based on the progression of your condition. The decision is individualized.
Syfovre does not reverse geographic atrophy. It aims to slow down the rate of progression, so it is likely a long-term maintenance treatment. Syfovre is injected directly into the eyes after a doctor uses a numbing solution. The application takes only minutes.
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