Vyepti (eptinezumab-jjmr) is a prescription intravenous (IV) infusion (an injection into a vein given over time). It’s used to help prevent migraine headaches.
There is currently limited data regarding the use of Vyepti during pregnancy in humans.
It’s not yet known if Vyepti poses a risk of miscarriage or problems with fetal development (commonly known as birth defects). However, animal studies have shown no negative developmental effects even at doses significantly higher than those used in humans.
Vyepti is a calcitonin gene-related peptide (CGRP) antagonist and belongs to a class of proteins called immunoglobulin G (IgG), a kind of monoclonal antibody. These proteins naturally cross into the placenta in pregnant people, especially during the third trimester. They provide the fetus with passive immunity (meaning the fetus doesn’t produce the immunity itself). Therefore, the developing fetus may be exposed to Vyepti during the later stages of pregnancy.
Yes, a pregnancy registry exists to monitor health outcomes for people who take Vyepti while pregnant. The registry collects health information about both the mother and the child to help researchers better understand the drug’s long-term safety profile.
You can enroll yourself or learn more by calling 855-810-8549 or visiting the registry website.
There’s no specific data on whether Vyepti passes into human milk or how it might affect milk production or a child who’s breastfed. IgG proteins are naturally occurring antibodies in breast milk, though they usually decrease after the first few days of breastfeeding. Since your body already includes similar proteins in your milk to support your baby’s immune system, it’s possible the drug may not cause any negative effects in your child.
Talk with your doctor if you have any questions or concerns about the safety of Vyepti treatment while pregnant or breastfeeding. They can help you weigh your medical need for Vyepti against any potential risks.
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