The two main categories for lung cancer are small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Large cell lung cancer (LCLC) is a type of NSCLC.

While the conditions share some similarities, there are also some differences, such as how quickly they grow, treatment options, and more.

SCLC and LCLC look different under a microscope, which can help medical professionals distinguish between them. SCLC cells look flat under a microscope. LCLC cells appear larger than a typical cell.

Although both types of lung cancer can grow quickly, SCLC generally tends to be more aggressive and faster growing.

Treatments for SCLC and LCLC can also differ. Chemotherapy is the main treatment for SCLC. Medical professionals may also recommend radiation therapy.

Surgery can help treat LCLC if the cancer does not affect a large part of the lungs or if it has not spread. Other treatments for LCLC can include:

  • chemotherapy
  • radiation therapy
  • immunotherapy
  • targeted drug therapy

SCLC and LCLC share some symptoms and risk factors.

Both conditions can cause symptoms such as:

Risk factors for SCLC and LCLC include:

  • smoking
  • exposure to secondhand smoke
  • exposure to radiation
  • exposure to asbestos
  • living in areas with high air pollution levels
  • having a family history of lung cancer

If a doctor suspects lung cancer, they may order imaging tests, such as an X-ray or MRI.

If the tests detect signs of lung cancer, an oncologist will perform a biopsy to remove a sample for examination under a microscope. This can help confirm the type of lung cancer, which is important for creating a suitable treatment plan.