Key takeaways

  • Attruby (acoramidis) can cause certain side effects, including diarrhea and pain in the upper abdomen.
  • Serious side effects haven’t been reported with Attruby.
  • If you experience side effects that are bothersome or difficult to tolerate, talk with your doctor.

Attruby is used in adults to treat wild-type or variant transthyretin-mediated amyloidosis cardiomyopathy (ATTR-CM).

Keep reading to learn about the common, mild, and serious side effects Attruby can cause.

Attruby can cause certain side effects, some more common than others. These side effects may be temporary, lasting a few days to weeks. Talk with your doctor if side effects do not go away, get worse, or become too difficult to tolerate.

Attruby’s commonly reported side effects include:

Mild side effects have been reported with Attruby. These include:

  • diarrhea
  • pain in the upper abdomen
  • mild increase in blood creatine
  • mild decrease in eGFR

In most cases, these side effects should be temporary, and some may be easily managed. But if you have symptoms that are ongoing or bothersome, talk with your doctor or pharmacist. Do not stop Attruby treatment unless your doctor recommends it.

Attruby may cause mild side effects other than those listed here. See the drug’s prescribing information for details.

For more information about some of these side effects, see “Tips for managing side effects.”

Serious side effects are not reported in Attruby’s prescribing information.

However, if you develop serious side effects while taking Attruby, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Sharing your experience helps make medication safer for everyone by giving doctors and researchers more information about how the drug works in real life. If you develop a side effect during treatment with Attruby and want to tell the FDA about it, visit MedWatch or call 800-FDA-1088.

Allergic reaction

For some people, Attruby can cause an allergic reaction.

But this side effect wasn’t reported in the drug’s studies.

In general, symptoms of an allergic reaction can be mild or serious.

What might help

If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest a treatment to manage your symptoms and can determine whether you should continue Attruby treatment.

If you have symptoms of a severe allergic reaction, such as swelling or difficulty breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care.

If your doctor confirms you’ve had a serious allergic reaction to Attruby, they may have you switch to a different treatment.

There may be things you can do to help make certain Attruby side effects more manageable. If you have ongoing, worsening, or bothersome side effects, talk with your doctor or pharmacist. They can suggest tips for managing them or recommend other available treatment options for your condition.

Diarrhea

Diarrhea was a side effect reported in studies of Attruby. Steps you can take to manage symptoms associated with this side effect include:

Medical Perspective

“Diarrhea can cause your body to lose fluids and important electrolytes, so staying well hydrated is especially important. Drinking fluids regularly throughout the day, including water and oral rehydration solutions or electrolyte-containing beverages, can help replace lost fluids and minerals and reduce the risk of dehydration.”

— Olivia Taylor, PharmD, BCPS

Learn about ways to rehydrate quickly.

Quotes represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Pain in the upper abdomen

Pain in the upper abdomen was a side effect reported in studies of Attruby. Steps you can take to manage symptoms associated with this side effect include:

  • taking the drug with food
  • maintain adequate hydration
  • reducing your intake of foods that may irritate your stomach, such as foods that are high in fat

Both Attruby and Vyndamax are approved to treat ATTR. Attruby’s prescribing information lists diarrhea, pain in the upper abdomen, and changes in blood creatine and eGFR as side effects. Although side effects of taking Vyndamax may be possible, the prescribing information doesn’t list any.

If you would like more information on the side effects of Attruby or Vyndamax, talk with your doctor or pharmacist.

Before taking Attruby, discuss your health history with your doctor. Attruby may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if any of the following apply to you:

Disclaimer: While Healthline strives for factual, comprehensive, and current information, this article is not a substitute for a licensed healthcare professional’s expertise. Always consult a doctor before taking or discontinuing any medication. Drug information is subject to change and may not cover all uses, directions, precautions, warnings, interactions, reactions, or adverse effects. The lack of a warning does not guarantee a drug’s safety, effectiveness, or appropriateness for all patients or specific uses. Learn more about our approach to content integrity.