Key takeaways
- Only inject Repatha (evolocumab) on its scheduled day. Do not inject a dose in advance.
- The timing of your Repatha dose on an injection day isn’t important, so you can adjust it as needed on that day.
- If you miss a dose of Repatha, the timing of your next injection depends on your prescribed schedule and how many days have passed since the missed dose was due. If you miss a dose, follow your doctor’s instructions or ask your pharmacist for help.
Repatha (evolocumab) is a prescription biologic drug. Doctors may prescribe Repatha for adults and certain children to reduce high cholesterol or some risks in people with heart disease. Doctors may sometimes prescribe other medications with Repatha, such as statins, which can also help lower cholesterol.
Typically, you inject Repatha once every 2 weeks or once per month. This article gives a brief overview of the usual doses and dosing schedule.
Do not inject Repatha earlier than your scheduled injection day, even when traveling. This instruction applies to any dose, including injections of 140 milligrams (mg) or 420 mg. The drug manufacturer doesn’t provide recommendations for injecting Repatha doses early.
The dosage you’re prescribed for Repatha depends on the condition you’re administering the drug to treat. The typical dosing schedule is either:
- 140 milligrams (mg) once every 2 weeks
- 420 mg once per month
Your doctor will prescribe the best dose of Repatha for you. They’ll also instruct you on how often to inject your dose. Always follow your doctor’s dosage instructions.
Inject Repatha exactly as your doctor prescribes. If you inject Repatha more often than prescribed, you may have side effects or overdose symptoms.
If you inject more than the recommended amount of Repatha, call your doctor right away or get emergency medical attention. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource.
You can inject Repatha at any time of the day that’s convenient for you. And Repatha isn’t known to interact with food, so it doesn’t matter whether you inject it close to a mealtime.
Choose a time of day that fits your schedule and you’ll likely remember. You can adjust the timing of your dose as needed on its scheduled day.
If you miss a Repatha injection, when you inject your next dose depends on how much time passes after your missed dose’s due date:
- If fewer than 7 days pass since your missed dose’s due date: Inject your next dose as soon as possible.
- If more than 7 days pass since your missed dose’s due date:
- For doses scheduled once every 2 weeks: Skip the missed dose. Then, inject the next dose based on your original schedule.
- For doses scheduled once per month: Inject the missed dose. Then, start a new schedule based on this date.
If you’re not sure when to inject Repatha after a missed dose, ask your doctor or pharmacist.
Do not inject Repatha earlier than your scheduled dosage day, such as a day or two early. Your doctor will instruct you on how and when to inject Repatha.
Typically, you’ll inject Repatha once every 2 weeks or once per month. Injecting Repatha more often than prescribed may cause you to have side effects or overdose symptoms.
You can inject Repatha at any time on its scheduled day, with or without meals. If needed, you can shift from your usual dosing time on a scheduled dosing day. This shift in time may be more convenient during travel.
Follow your doctor’s instructions if you miss a dose of Repatha. These instructions depend on which dosage schedule of Repatha they prescribe to you.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.