The prescribed dosage for Rezdiffra (resmetirom) may depend on a person’s individual treatment plan. Factors like your medical history and body weight may affect your dosage of Rezdiffra.

Rezdiffra (resmetirom) is a prescription drug used to treat metabolic dysfunction-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH) in adults in certain situations. (MASH is a type of nonalcoholic fatty liver disease.) The drug comes as an oral tablet. It’s usually taken once per day.

This article describes the dosage of Rezdiffra, its strengths, and how to take it. To learn more about Rezdiffra, including its side effects and uses, read this in-depth Rezdiffra article.

Note: Rezdiffra received accelerated approval from the Food and Drug Administration (FDA) to treat NASH. Accelerated approval is based on information from early drug studies. The FDA will make a decision about full approval after more studies are completed.

The following information describes dosages that are commonly used or recommended for Rezdiffra. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs. In some cases, doctors may adjust your dosage from those mentioned here.

Rezdiffra forms

Rezdiffra is available as an oral tablet.

Rezdiffra strengths

Rezdiffra comes in three strengths:

  • 60 milligrams (mg)
  • 80 mg
  • 100 mg

Rezdiffra is approved to treat MASH. The typical Rezdiffra dosage for adults with NASH depends on a person’s body weight in kilograms (kg). For reference, 1 kg is about 2.2 pounds (lb).

For someone who weighs less than 100 kg (about 220 lb), the typical dosage of Rezdiffra is 80 mg once per day.

For someone who weighs more than or equal to 100 kg (about 220 lb), the typical dosage of Rezdiffra is 100 mg once per day.

Always follow your doctor’s instructions. Notify them if you experience any side effects that may prevent you from taking your medication.

Your doctor or pharmacist will give you specific instructions for taking Rezdiffra. Typically, recommendations for taking Rezdiffra include:

  • taking your dose with or without food
  • if you take certain other medications, your dosage of Rezdiffra may need to be lowered
  • it’s best to take it around the same time each day
  • the drugmaker hasn’t stated whether Rezdiffra tablets can be chewed, crushed, or split

How long do you take Rezdiffra?

Rezdiffra is usually a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term once you reach your maintenance dose.

Do not take more Rezdiffra than your doctor prescribes, as this can lead to harmful effects.

What to do in case you take too much Rezdiffra

Call your doctor right away if you think you’ve taken too much Rezdiffra. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.