Takhzyro (lanadelumab-flyo) is a prescription drug used to help prevent severe swelling attacks caused by hereditary angioedema (HAE). Takhzyro’s cost may depend on factors such as your dosage and whether you have health insurance.

Note: The reason “-flyo” appears at the end of the drug’s name is to show that it is distinct from similar medications that may be created in the future.

The price you pay for Takhzyro can vary. Your cost may depend on your treatment plan, your insurance coverage (if you have it), and the pharmacy you use. When you receive injections from your doctor rather than self-injecting it at home, your cost may also depend on how much you have to pay for an office visit to receive Takhzyro.

To find out how much you’ll pay for Takhzyro, talk with your doctor, pharmacist, or insurance provider.

Takhzyro is a biologic drug, which means it’s made from parts of living organisms. It doesn’t come in a biosimilar form. Biosimilars are like generic drugs. Unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.

Why is there such a cost difference between biologic drugs and biosimilar drugs?

Biologic drugs can be expensive because of the research and testing needed to ensure their safety and effectiveness. The manufacturer of a biologic drug can sell it exclusively for up to 12 years. When the biologic drug’s patent expires, other drugmakers can create biosimilar versions.

This competition in the market may lead to lower costs for biosimilars. And because biosimilars are very similar to biologic drugs, they don’t need to be studied again. This can also lead to lower costs for biosimilars.

If you take Takhzyro long term, you may be able to lower your costs by getting a 90-day supply of your medication.

You may be able to get a 90-day supply of Takhzyro if approved by your insurance company. This could reduce your number of trips to the pharmacy and help lower the cost of Takhzyro. If you’re interested in a 90-day supply of this drug, talk with your doctor, pharmacist, or insurance provider.

If you need help covering the cost of Takhzyro or understanding your insurance, check out these resources:

On these pages, you can find insurance information, details on drug assistance programs, and links to savings cards and other services.

If you have questions about how to pay for your prescription, talk with your doctor or pharmacist.

Below are answers to some frequently asked questions about Takhzyro and cost.

How does the cost of Takhzyro compare with that of similar drugs, such as Berinert or Firazyr?

The cost of Takhzyro compared with the cost of C1 esterase inhibitor (human) (Berinert) or icatibant acetate (Firazyr) can depend on several factors.

For example, Takhzyro comes in a different form than Berinert, which may affect the cost. Takhzyro and Firazyr are both given as injections under the skin. Berinert is given as an intravenous (IV) infusion, which is an injection into a vein given over a period of time.

Other factors that may affect how much you pay include:

  • whether there are any savings programs available for the drug you’re prescribed
  • whether you have insurance or are paying out of pocket
  • how long your treatment lasts
  • whether you receive the medication in a healthcare facility or self-inject it at home

If you have questions about the cost of Takhzyro compared with the cost of similar medications, talk with your doctor, pharmacist, or insurance provider. They can share more details on treatment costs based on your specific situation.

Is Takhzyro covered by Medicare?

It’s possible. To find out whether your Medicare plan covers the cost of Takhzyro, call your plan provider. There are many different types of Medicare plans, and your cost and coverage depend on your particular plan’s benefits.

Your final cost may also depend on whether you (or a caregiver) give Takhzyro injections at home or if you receive doses at a doctor’s office or clinic.

Keep in mind that your plan may have prior authorization requirements before it will cover Takhzyro. (See the “Prior authorization” section for more information.)

You can also ask your doctor about the cost of Takhzyro if you have Medicare.

If you have insurance, you may need to get prior authorization before your insurance provider will cover Takhzyro. This means your insurer and your doctor will discuss Takhzyro in regard to your treatment. Then the insurance company will determine whether the drug is covered. If Takhzyro requires prior authorization and you don’t receive it before you start treatment, you could pay the full cost of the drug.

Be sure to ask your insurance company whether Takhzyro requires prior authorization.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.